Virtual Data Rooms (VDRs) are safe and reliable methods to access confidential documents during business transactions. VDRs can be used to conduct due diligence during mergers and acquisitions. They also assist businesses organize important documents and share them with investors and other stakeholders. VDRs can also be used to store and manage contracts, invoices, and other legal documents like estate planning and litigation.
Members should be aware of the procedures and equipment installed on their vessels using VDR/SVDR. It is also recommended to upgrade and replace any that are outdated or do not meet minimum safety requirements.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the production of proteins that are involved in a myriad of physiological processes.
The VDR is found in neurons, as well as a subset glial cells that form part of the brain. In the primary hippocampal cells of rodents, VDR immunoreactivity was detected in oligodendrocytes. The VDR is also present in human neuroblastoma and astrocytes. Treatment of HL-60 myeloblast leukemia cells with 1,25(OH)2D3 induced monocyte-like differentiation with an increase in the levels of VDR protein. This effect was blocked by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.
